Biochem Biophys Res Commun. 2005 Dec 9;338(1):25-33. Epub 2005 Aug 15.

Regulation of cyclooxygenase catalysis by hydroperoxides.

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Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. richard.j.kulmacz@uth.tmc.edu

Abstract

Activation of cyclooxygenase catalysis in prostaglandin H synthase-1 and -2 by peroxide-dependent formation of a tyrosyl radical is emerging as an important part of regulating cellular production of bioactive prostanoids. This review discusses the mechanism of tyrosyl radical formation and the influence of peroxide, fatty acid, peroxidase cosubstrate, and protein structure on the activation process and cyclooxygenase catalysis.

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