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1: Peptides. 2005 Sep;26(9):1598-601. Epub 2005 Mar 26.Click here to read Links

Gastrokinetic effect of ghrelin analog RC-1139 in the rat. Effect on post-operative and on morphine induced ileus.

Poitras P, Polvino WJ, Rocheleau B.

Centre de recherche, CHUM, Hôpital Saint-Luc, 264, East René-Lévesque Blvd., Université de Montréal, Montréal, Que., Canada H2X 1P1.

We aimed to confirm the gastrokinetic effect of ghrelin analog, RC-1139, in the presence of opiates. Gastric emptying was verified in rats by counting stomach residue 15 min after gavage of methylcellulose. Normal rats: RC-1139 (0, 0.25, 1.0, 2.5 mg/kg i.v.) decreased methylcellulose left in stomach (47, 36, 12, 10% of ingested solution). Post-operative ileus (post-op. ileus) ileus: gastric residue decreased from 88 to 66, 53, 51% with RC-1139 0, 1.0, 2.5, 10 mg/kg. Morphine in post-op. ileus: gastroparesis was corrected at 10 mg/kg (54%). Ghrelin analog RC-1139 is a potent gastrokinetic in rat; it reversed gastric post-op. ileus, even in the presence of opiates.

PMID: 16112398 [PubMed - indexed for MEDLINE]

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