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Stroke. 2005 Sep;36(9):2012-4. Epub 2005 Aug 18.

Ischemic stroke subtypes and thrombophilia in young and elderly Brazilian stroke patients admitted to a rehabilitation hospital.

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  • 1Neurology Department, The Sarah Network of Rehabilitation Hospitals, Sarah Hospital, Brasilia, DF, Brazil. javier@bsb.sarah.br

Abstract

BACKGROUND AND PURPOSE:

We sought to examine ischemic stroke subtypes and prevalence of thrombophilia in Brazilian stroke patients.

METHOD:

A total of 130 consecutive young and 200 elderly stroke patients were studied.

RESULTS:

Prevalence of thrombophilia was, respectively: protein S deficiency (11.5% versus 5.5%), protein C deficiency (0.76% versus 1%), resistance to activated protein C (2.3% versus 3.5%), mutation in V Leiden factor (1.5% versus 2%), antithrombin III deficiency (0% versus 0%), lupus anticoagulant (0% versus 0.5%), anticardiolipin antibodies (3% versus 10%; P=0.01), hyperhomocysteinemia (31.5% versus 53.5%; P=0.0001), mutation of the MTHFR gene in homocigosis (10% versus 5%), and heterocigosis (27.6% versus 41.9%; P=0.01).

CONCLUSIONS:

Prothrombotic conditions were more frequent in stroke of undetermined cause.

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