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Addict Biol. 2005 Sep;10(3):293-7.

Neuroimaging studies of brain corpus striatum changes among heroin-dependent patients treated with herbal medicine, U'finer capsule.

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  • 1Department of Nuclear Medicine, Shenzhen Hospital, Peking University, Shenzhen, China.

Abstract

Chronic exposure to heroin is associated with structural changes in dopaminergic (DA) neurones. The present study examined the effects of a new herbal medicine, U'finer capsule, on the brain corpus striatum and DA systems, comparing pre- and post- treatment in 36 heroin-dependent patients. Neuroimaging studies were performed by using single photon emission computed tomography (SPECT) with 99mTc-TRODAT-1 as radiotracer. The results show that U'finer significantly repaired the damaged bilateral corpus striatum, restoring it to a 'panda eye' shape, analogous in size and shape to that of the healthy volunteers. DA transporter (DAT) function in the bilateral corpus striatum was restored to a normal state after recovery from neurotoxic insult. These findings suggest that U'finer is a reliable herbal medicine in the treatment of heroin dependency.

PMID:
16109593
[PubMed - indexed for MEDLINE]
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