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Ethn Dis. 2005 Summer;15(3):429-35.

Distribution and determinants of coronary artery disease in an urban Pakistani setting.

Author information

  • 1Department of Epidemiology; University of Pittsburgh, Pittsburgh, PA 15101, USA. sud0@pitt.edu

Erratum in

  • Ethn Dis. 2006 Winter;16(1):309. MacLean, David D [added]; LaPorte, Ronald E [added]; Joffres, Michel [added].

Abstract

OBJECTIVE:

We assessed the distribution of coronary artery disease (CAD) and its association with the major biological risk factors and behaviors among Pakistanis presenting at a tertiary care hospital in Karachi, Pakistan.

METHOD:

An epidemiologic cross-sectional study was conducted at the Aga Khan University Hospital (a teaching hospital) in Karachi, Pakistan. A total of 600 adult (> or =18 years of age) patients visiting family practice clinics for general check-up were included. The association of biological risk factors with CAD (smoking, obesity [body mass index (BMI)], hypertension, family history of ischemic heart diseases [IHD], sedentary lifestyle, diabetes mellitus, total cholesterol, low density lipoprotein [LDL] levels, high density lipoprotein [HDL] levels, and triglycerides) were assessed.

RESULTS:

On univariate analysis, age > or =40 years, early menopause, BMI > or =29.9 kg/m2, diabetes, high cholesterol, and positive family history of IHD were independently associated with CAD. We found age > or =40 years, diabetes, and positive family history of IHD strongly related with CAD on multivariate analysis.

CONCLUSION:

Looking at the strong association of major risk factors with CAD, the unique characteristics of Pakistanis must be studied in depth, with focus on high-risk groups.

PMID:
16108303
[PubMed - indexed for MEDLINE]
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