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1: Genesis. 2005 Oct;43(2):80-6.Click here to read Links

Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene.

Park SY, Wang X, Chen Z, Powers AC, Magnuson MA, Head WS, Piston DW, Bell GI.

Department of Biochemistry and Molecular Biology, and the Howard Hughes Medical Institute, The University of Chicago, Chicago , Illinois, USA. sooyoung@uchicago.edu

We generated transgenic mice expressing firefly (Photinus pyralis) luciferase (luc) under the control of the mouse insulin I promoter (MIP). The mice have normal glucose tolerance and pancreatic islet architecture. The luciferase-expressing beta cells can be readily visualized in living mice using whole-body bioluminescent imaging. The MIP-luc transgenic mice may be useful for monitoring changes in beta cell function or mass in living animals with normal or altered metabolic states. genesis 43:80-86, 2005. (c) 2005 Wiley-Liss, Inc.

PMID: 16108006 [PubMed - indexed for MEDLINE]