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Nature. 2005 Aug 18;436(7053):946-52.

Adaptive immune responses in acute and chronic hepatitis C virus infection.

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  • 1Center for Vaccines and Immunity, Columbus Children's Research Institute, Columbus, Ohio OH 43205, USA.


The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant cause of human illness and death globally. Recent studies have yielded important insights into immunity to HCV, in particular revealing the central role of T cells in viral control and clearance. Other key features of adaptive immune responses remain obscure, including mechanisms by which T cells control HCV replication, the role of antibodies in conferring protection and how cellular and humoral immunity are subverted in persistent infection.

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