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Int J Tuberc Lung Dis. 2005 Aug;9(8):896-900.

Anti-tuberculosis drug resistance in patients with HIV and tuberculosis in South India.

Author information

  • 1Tuberculosis Research Centre, Chennai, Tamil Nadu, India. doctorsoumya@yahoo.com

Abstract

SETTING:

Tuberculosis Research Centre clinics at Chennai and Madurai, Tamil Nadu, South India.

OBJECTIVES:

To investigate the prevalence and pattern of drug resistance among patients with HIV and pulmonary tuberculosis (PTB).

DESIGN:

Prospective cohort study of HIV-positive patients with PTB between January 2001 and May 2003. Sputum mycobacterial culture and drug susceptibility testing were performed.

RESULTS:

A total of 204 patients with positive sputum cultures for Mycobacterium tuberculosis were included; 167 of them were new cases, and 37 had a history of previous anti-tuberculosis treatment for > 1 month. Among the former, resistance to isoniazid (INH) was observed in 22 (13%) and MDR-TB in 7 (4.2%). Reported resistance rates in this geographic area among new cases ranged from 15% to 28% for INH and 2.8% to 3.4% for MDR (INH + rifampicin [RMP]). In contrast, among HIV-positive patients with a history of previous treatment, resistance was found to INH in 10 (27%) and to RMP in 7 (18.9%), while MDR-TB was seen in 5 (13.5%) patients.

CONCLUSION:

Among new TB patients, MDR-TB is marginally higher in HIV-positive patients than in the non-HIV-infected population in this region. Standard treatment guidelines should be followed. Higher rates of drug resistance are observed among previously treated patients.

PMID:
16104637
[PubMed - indexed for MEDLINE]
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