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Nucleic Acids Res. 2005 Aug 15;33(14):4618-25. Print 2005.

DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE.

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  • 1Department of Microbiology and Tumor biology Box 280, Karolinska Institutet, 171 77 Stockholm, Sweden.

Abstract

POU domain proteins contain a bipartite DNA-binding element that can confer allosteric control of coactivator recruitment. Dimerization of Oct-1 and Oct-2 on palindromic response elements results in the conformational dependent inclusion or exclusion of the transcriptional coactivator OBF-1. In this paper, we demonstrate that Oct-1 and Oct-2 can function as transcriptional repressors by recruiting and physically interacting with members of the Grg/TLE family of corepressors. In accordance with a model of DNA induced cofactor assembly, and analogous to the recruitment of the OBF-1 coactivator, the different Grg/TLE members can discriminate between both Oct-1 and Oct-2, and the monomeric or dimeric nature of the POU/DNA complex.

PMID:
16103132
[PubMed - indexed for MEDLINE]
PMCID:
PMC1187819
Free PMC Article

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