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Behav Brain Res. 2005 Nov 7;164(2):188-96.

Mice deficient in microtubule-associated protein MAP1B show a distinct behavioral phenotype and altered retina function.

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  • 1Clinic of Internal Medicine and Infectious Diseases, University of Veterinary Medicine, Veterinaerplatz 1, A-1210 Vienna, Austria.


We investigated mice deficient for the microtubule-associated protein MAP1B, a cytoskeletal element highly expressed in the developing nervous system, for altered performance in behavior, learning, and memory. Using the multiple T-maze, the open field and the Morris water maze we found that mice homozygous for a deletion of the MAP1B gene demonstrate impaired locomotor activity most likely correlated to a lack of physical endurance in general. In contrast, there were no significant differences in cognitive function and memory retention. In addition, we performed electroretinography and observed a reduction of the a-wave amplitude in response to single flash, white light stimulation. Taken together, these data provide further evidence for an important role of MAP1B in synaptic neurotransmission.

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