Neuron. 2005 Aug 18;47(4):471-3.

Apoer2: a reelin receptor to remember.

Source

The Cain Foundation Laboratories, Texas Children's Hospital, Departmrnt of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.

Abstract

The extracellular protein Reelin is crucial for neuronal positioning during brain development, but its expression persists long after cell migration is completed. In this issue of Neuron, Beffert et al. demonstrate that Reelin exerts an additional function in the mature brain, to modulate synaptic plasticity and to favor memory formation. This activity is carried out exquisitely by the Apoer2 receptor and critically requires the presence of an alternatively spliced exon. This exon encodes an intracellular domain that interacts with postsynaptic proteins and promotes binding and phosphorylation of NMDA receptors.

Comment on

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. [Neuron. 2005]
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2.Beffert U, Weeber EJ, Durudas A, Qiu S, Masiulis I, Sweatt JD, Li WP, Adelmann G, Frotscher M, Hammer RE, et al. Neuron. 2005 Aug 18; 47(4):567-79.

PMID:: 16102527; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. [Neuron. 2005]
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2.
Beffert U, Weeber EJ, Durudas A, Qiu S, Masiulis I, Sweatt JD, Li WP, Adelmann G, Frotscher M, Hammer RE, et al. Neuron. 2005 Aug 18; 47(4):567-79.
Review Reelin, lipoprotein receptors and synaptic plasticity. [Nat Rev Neurosci. 2006]
Review Reelin, lipoprotein receptors and synaptic plasticity.
Herz J, Chen Y. Nat Rev Neurosci. 2006 Nov; 7(11):850-9.
Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin. [Neurosci Res. 2009]
Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin.
Hibi T, Mizutani M, Baba A, Hattori M. Neurosci Res. 2009 Apr; 63(4):251-8. Epub 2009 Jan 9.
Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. [J Biol Chem. 2002]
Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning.
Weeber EJ, Beffert U, Jones C, Christian JM, Forster E, Sweatt JD, Herz J. J Biol Chem. 2002 Oct 18; 277(42):39944-52. Epub 2002 Aug 7.
Review Reelin and apoE actions on signal transduction, synaptic function and memory formation. [Neuron Glia Biol. 2008]
Review Reelin and apoE actions on signal transduction, synaptic function and memory formation.
Rogers JT, Weeber EJ. Neuron Glia Biol. 2008 Aug; 4(3):259-70. Epub 2009 Aug 13.

See reviews... See all...

Cited by 5 PubMed Central articles

Vldlr overexpression causes hyperactivity in rats. [Mol Autism. 2012]
Vldlr overexpression causes hyperactivity in rats.
Iwata K, Izumo N, Matsuzaki H, Manabe T, Ishibashi Y, Ichitani Y, Yamada K, Thanseem I, Anitha A, Vasu MM, et al. Mol Autism. 2012 Oct 30; 3(1):11. Epub 2012 Oct 30.
Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. [Cold Spring Harb Perspect Med....]
Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease.
Holtzman DM, Herz J, Bu G. Cold Spring Harb Perspect Med. 2012 Mar; 2(3):a006312.
Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors. [J Neuroinflammation. 2011]
Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors.
Liu L, Aboud O, Jones RA, Mrak RE, Griffin WS, Barger SW. J Neuroinflammation. 2011 Dec 15; 8:175. Epub 2011 Dec 15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Apoer2: a reelin receptor to remember.
Apoer2: a reelin receptor to remember.
Neuron. 2005 Aug 18 ;47(4):471-3.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Apoer2: a reelin receptor to remember.

Source

Abstract

Comment on

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 5 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information