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    Protein Pept Lett. 2005 Aug;12(6):513-9.

    The role of Abeta peptides in Alzheimer's disease.

    Tickler AK, Wade JD, Separovic F.

    School of Chemistry, University of Melbourne, VIC 3010, Australia.

    The Abeta peptide has been identified as central to the onset and development of Alzheimer's disease (AD) and several hypotheses about toxicity involving Abeta peptides have been proposed including mechanisms of oxidative stress and disruption of calcium homeostasis. The biology, structure and physical properties of Abeta peptides are discussed, as well as existing therapeutics and future strategies for the treatment of AD.

    PMID: 16101387 [PubMed - indexed for MEDLINE]

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