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Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):585-95.

MyoD and the transcriptional control of myogenesis.

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  • 1Colorado College, Colorado Springs, CO 80903, USA. Charlotte.Berkes@ucsf.edu


The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4 have critical roles in skeletal muscle development. Together with the Mef2 proteins and E proteins, these transcription factors are responsible for coordinating muscle-specific gene expression in the developing embryo. This review highlights recent studies regarding the molecular mechanisms by which the muscle-specific myogenic bHLH proteins interact with other regulatory factors to coordinate gene expression in a controlled and ordered manner.

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