Curr Opin Cell Biol. 2005 Oct;17(5):548-58.

Molecular requirements for epithelial-mesenchymal transition during tumor progression.

Source

Department of Dermatology, Vienna Medical University, Währinger Gürtel 18-20, 1090 Vienna, Austria.

Abstract

Epithelial-mesenchymal transitions (EMTs) occur as key steps during embryonic morphogenesis, and are now implicated in the progression of primary tumors towards metastases. Recent advances have fostered a more detailed understanding of molecular mechanisms and networks governing EMT in tumor progression. Besides TGFbeta and RTK/Ras signaling, autocrine factors and Wnt-, Notch-, Hedgehog- and NF-kappaB-dependent pathways were found to contribute to EMT. Repression of E-cadherin by transcriptional regulators such as Snail or Twist emerges as one critical step driving EMT, and this stage is currently being molecularly linked with many of the new players. Increasing evidence suggests that EMT plays a specific role in the migration of cells from a primary tumor into the circulation and may provide a rationale for developing more effective cancer therapies.

PMID:: 16098727; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Cadherins

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Review Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. [Cells Tissues Organs. 2007]
Review Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions.
Doble BW, Woodgett JR. Cells Tissues Organs. 2007; 185(1-3):73-84.
Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition. [Cancer Res. 2008]
Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition.
Arima Y, Inoue Y, Shibata T, Hayashi H, Nagano O, Saya H, Taya Y. Cancer Res. 2008 Jul 1; 68(13):5104-12.
A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis. [Mol Cell Biol. 2009]
A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis.
Smit MA, Geiger TR, Song JY, Gitelman I, Peeper DS. Mol Cell Biol. 2009 Jul; 29(13):3722-37. Epub 2009 May 4.
Review Epithelial-mesenchymal transition in gastric cancer (Review). [Int J Oncol. 2005]
Review Epithelial-mesenchymal transition in gastric cancer (Review).
Katoh M. Int J Oncol. 2005 Dec; 27(6):1677-83.
Review Epithelial-mesenchymal transition in ovarian cancer progression: a crucial role for the endothelin axis. [Cells Tissues Organs. 2007]
Review Epithelial-mesenchymal transition in ovarian cancer progression: a crucial role for the endothelin axis.
Bagnato A, Rosanò L. Cells Tissues Organs. 2007; 185(1-3):85-94.

See reviews... See all...

Cited by over 100 PubMed Central articles

Gene Expression Profiles of the NCI-60 Human Tumor Cell Lines Define Molecular Interaction Networks Governing Cell Migration Processes. [PLoS One. 2012]
Gene Expression Profiles of the NCI-60 Human Tumor Cell Lines Define Molecular Interaction Networks Governing Cell Migration Processes.
Kohn KW, Zeeberg BR, Reinhold WC, Sunshine M, Luna A, Pommier Y. PLoS One. 2012; 7(5):e35716. Epub 2012 May 3.
Implication of stem cells in the biology and therapy of head and neck cancer. [GMS Curr Top Otorhinolaryngol ...]
Implication of stem cells in the biology and therapy of head and neck cancer.
Wollenberg B. GMS Curr Top Otorhinolaryngol Head Neck Surg. 2011; 10:Doc01. Epub 2012 Apr 26.
EGF-Induced EMT and Invasiveness in Serous Borderline Ovarian Tumor Cells: A Possible Step in the Transition to Low-Grade Serous Carcinoma Cells? [PLoS One. 2012]
EGF-Induced EMT and Invasiveness in Serous Borderline Ovarian Tumor Cells: A Possible Step in the Transition to Low-Grade Serous Carcinoma Cells?
Cheng JC, Auersperg N, Leung PC. PLoS One. 2012; 7(3):e34071. Epub 2012 Mar 30.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Molecular requirements for epithelial-mesenchymal transition during tumor progre...
Molecular requirements for epithelial-mesenchymal transition during tumor progression.
Curr Opin Cell Biol. 2005 Oct ;17(5):548-58.

PubMed
Memory T cell homeostasis and senescence during aging.
Memory T cell homeostasis and senescence during aging.
Curr Opin Immunol. 2005 Oct ;17(5):480-5.

PubMed
Depression in patients with acute traumatic brain injury.
Depression in patients with acute traumatic brain injury.
Am J Psychiatry. 1992 Jul ;149(7):918-23.

PubMed
Signalling pathway in the induction of neurite outgrowth in human mesenchymal st...
Signalling pathway in the induction of neurite outgrowth in human mesenchymal stem cells.
Cell Signal. 2006 Apr ;18(4):519-30. Epub 2005 Aug 11 .

PubMed
Differences in the effects of divorce on major depression in men and women.
Differences in the effects of divorce on major depression in men and women.
Am J Psychiatry. 1992 Jul ;149(7):914-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: