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Trends Genet. 2005 Oct;21(10):548-51.

Do disparate mechanisms of duplication add similar genes to the genome?

Author information

  • 1Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 90305-5020, USA. jerel@stanford.edu

Abstract

Gene duplication is the fundamental source of new genes. Biases in duplication have profound implications for the dynamics of gene content during evolution. In this article, we compare genes arising from whole gene duplication (WGD), smaller scale duplication (SSD) and singletons in Saccharomyces cerevisiae. Our results demonstrate that genes duplicated by WGD and SSD are similarly biased with respect to codon bias and evolutionary rate, although differing significantly in their functional constituency.

PMID:
16098632
[PubMed - indexed for MEDLINE]
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