Expert Rev Proteomics. 2005 Aug;2(4):541-51.

Building the mitochondrial proteome.

Source

Department of Cellular Biology, University of Geneva, 30 quai E. Ansermet, 1205 Geneva, Switzerland. sandrine.dacruz@cellbio.unige.ch

Abstract

Mitochondria are essential organelles for cellular homeostasis. A variety of pathologies including cancer, myopathies, diabetes, obesity, aging and neurodegenerative diseases are linked to mitochondrial dysfunction. Therefore, mapping the different components of mitochondria is of particular interest to gain further understanding of such diseases. In recent years, proteomics-based approaches have been developed in attempts to determine the complete set of mitochondrial proteins in yeast, plants and mammals. In addition, proteomics-based methods have been applied not only to the analysis of protein function in the organelle, but also to identify biomarkers for diagnosis and therapeutic targets of specific pathologies associated with mitochondria. Altogether, it is becoming clear that proteomics is a powerful tool not only to identify currently unknown components of the mitochondrion, but also to study the different roles of the organelle in cellular homeostasis.

PMID:: 16097887; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

Saccharomyces Genome Database

Supplemental Content

Save items

Related citations in PubMed

Review Mammalian mitochondrial proteomics: insights into mitochondrial functions and mitochondria-related diseases. [Expert Rev Proteomics. 2010]
Review Mammalian mitochondrial proteomics: insights into mitochondrial functions and mitochondria-related diseases.
Chen X, Li J, Hou J, Xie Z, Yang F. Expert Rev Proteomics. 2010 Jun; 7(3):333-45.
The mitochondrial proteome database: MitoP2. [Methods Enzymol. 2009]
The mitochondrial proteome database: MitoP2.
Elstner M, Andreoli C, Klopstock T, Meitinger T, Prokisch H. Methods Enzymol. 2009; 457:3-20.
Review Mitochondriomics or what makes us breathe. [Trends Genet. 2004]
Review Mitochondriomics or what makes us breathe.
Reichert AS, Neupert W. Trends Genet. 2004 Nov; 20(11):555-62.
Integrative analysis of the mitochondrial proteome in yeast. [PLoS Biol. 2004]
Integrative analysis of the mitochondrial proteome in yeast.
Prokisch H, Scharfe C, Camp DG 2nd, Xiao W, David L, Andreoli C, Monroe ME, Moore RJ, Gritsenko MA, Kozany C, et al. PLoS Biol. 2004 Jun; 2(6):e160. Epub 2004 Jun 15.
Review The human mitochondrial proteome: oxidative stress, protein modifications and oxidative phosphorylation. [Int J Biochem Cell Biol. 2005]
Review The human mitochondrial proteome: oxidative stress, protein modifications and oxidative phosphorylation.
Gibson BW. Int J Biochem Cell Biol. 2005 May; 37(5):927-34. Epub 2005 Jan 8.

See reviews... See all...

Cited by 5 PubMed Central articles

Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging. [J Aging Res. 2011]
Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging.
Staunton L, O'Connell K, Ohlendieck K. J Aging Res. 2011 Mar 7; 2011:908035. Epub 2011 Mar 7.
Review Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes. [Philos Trans R Soc Lond B Biol...]
Review Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes.
Lithgow T, Schneider A. Philos Trans R Soc Lond B Biol Sci. 2010 Mar 12; 365(1541):799-817.
Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS. [J Proteomics. 2009]
Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS.
Lefort N, Yi Z, Bowen B, Glancy B, De Filippis EA, Mapes R, Hwang H, Flynn CR, Willis WT, Civitarese A, et al. J Proteomics. 2009 Aug 20; 72(6):1046-60. Epub 2009 Jun 28.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Building the mitochondrial proteome.
Building the mitochondrial proteome.
Expert Rev Proteomics. 2005 Aug ;2(4):541-51.

PubMed
Lipid and insulin concentrations in obese postmenopausal women: separate effects...
Lipid and insulin concentrations in obese postmenopausal women: separate effects of energy restriction and weight loss.
Am J Clin Nutr. 1992 Jul ;56(1):44-9.

PubMed
The influence of ultrasound on the mechanical properties of healing tendons in r...
The influence of ultrasound on the mechanical properties of healing tendons in rabbits.
Acta Orthop. 2005 Apr ;76(2):225-30.

PubMed
Postural synergies and their development.
Postural synergies and their development.
Neural Plast. 2005 ;12(2-3):119-30; discussion 263-72.

PubMed
[Obesity management knowledge, attitudes and practices of general practitioners ...
[Obesity management knowledge, attitudes and practices of general practitioners in southeastern France; results of a telephone survey].
Presse Med. 2005 Jun 18 ;34(11):769-75.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: