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Cell. 2005 Aug 12;122(3):317-8.

Splicing misplaced.

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  • 1National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.


Newly synthesized transcripts are usually spliced during transcription or immediately thereafter. So pre-mRNA splicing has been presumed to occur exclusively in the cell nucleus. In this issue of Cell, Denis et al. (2005) now report the presence of functional spliceosomes and signal-dependent pre-mRNA splicing in the cytoplasm of platelets.

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