Rapid synthesis of CDP840 with 2-pyrimidyl vinyl sulfide as a platform

Nobuhiro Muraoka; Masahiro Mineno; Kenichiro Itami; Jun-ichi Yoshida

doi:10.1021/jo0510437

Rapid synthesis of CDP840 with 2-pyrimidyl vinyl sulfide as a platform

J Org Chem. 2005 Aug 19;70(17):6933-6. doi: 10.1021/jo0510437.

Authors

Nobuhiro Muraoka¹, Masahiro Mineno, Kenichiro Itami, Jun-ichi Yoshida

Affiliation

¹ Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.

PMID: 16095319
DOI: 10.1021/jo0510437

Abstract

A rapid synthesis of CDP840 (a potential therapeutic agent for asthma), using 2-pyrimidyl vinyl sulfide as a platform, has been established. This method includes a stereoselective double Mizoroki-Heck-type arylation, a Liebeskind-Srogl-type cross-coupling reaction, and a Pd/C-catalyzed hydrogenation.