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Acta Paediatr. 2005 Apr;94(4):386-93.

Tight junctions, leaky intestines, and pediatric diseases.

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  • 1International Peace Maternity and Child Health Hospital, Shanghai, China.

Abstract

BACKGROUND:

Tight junctions (TJs) represent the major barrier within the paracellular pathway between intestinal epithelial cells. Disruption of TJs leads to intestinal hyperpermeability (the so-called "leaky gut") and is implicated in the pathogenesis of several acute and chronic pediatric disease entities that are likely to have their origin during infancy.

AIM:

This review provides an overview of evidence for the role of TJ breakdown in diseases such as systemic inflammatory response syndrome (SIRS), inflammatory bowel disease, type 1 diabetes, allergies, asthma, and autism.

CONCLUSION:

A better basic understanding of this structure might lead to prevention or treatment of these diseases using nutritional or other means.

PMID:
16092447
[PubMed - indexed for MEDLINE]
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