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Bioinformatics. 2005 Nov 1;21(21):4060-6. Epub 2005 Aug 9.

ProRule: a new database containing functional and structural information on PROSITE profiles.

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  • 1Swiss Institute of Bioinformatics (SIB), 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland.



Increase the discriminatory power of PROSITE profiles to facilitate function determination and provide biologically relevant information about domains detected by profiles for the annotation of proteins.


We have created a new database, ProRule, which contains additional information about PROSITE profiles. ProRule contains notably the position of structurally and/or functionally critical amino acids, as well as the condition they must fulfill to play their biological role. These supplementary data should help function determination and annotation of the UniProt Swiss-Prot knowledgebase. ProRule also contains information about the domain detected by the profile in the Swiss-Prot line format. Hence, ProRule can be used to make Swiss-Prot annotation more homogeneous and consistent. The format of ProRule can be extended to provide information about combination of domains.


ProRule can be accessed through ScanProsite at A file containing the rules will be made available under the PROSITE copyright conditions on our ftp site ( by the next PROSITE release.

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