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Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jun;71(6 Pt 1):061916. Epub 2005 Jun 23.

Internal noise stochastic resonance for intracellular calcium oscillations in a cell system.

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  • 1Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui, 230026, People's Republic of China.


By constructing a mesoscopic stochastic model for intracellular calcium oscillations in a cell system, we have investigated how the internal noise would influence the calcium oscillations of such a system using stochastic simulation methods and chemical Langevin method. It is found that stochastic calcium oscillations appear when the internal noise is considered, while the deterministic model only yields steady state. The performance of such oscillations undergoes a maximum with the variation of the internal noise level, indicating the occurrence of internal noise stochastic resonance. Interestingly, we find that the optimal system size matches well with the real cell size when the control parameter is tuned near the left Hopf bifurcation point, and such a match is robust to the variation of the control parameters.

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