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J Exp Med. 2005 Aug 15;202(4):473-7. Epub 2005 Aug 8.

IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel.

Author information

  • 1Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. lennon.vanda@mayo.edu

Abstract

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ. A serum immunoglobulin G autoantibody (NMO-IgG) serves as a specific marker for NMO. Here we show that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier. NMO may represent the first example of a novel class of autoimmune channelopathy.

PMID:
16087714
[PubMed - indexed for MEDLINE]
PMCID:
PMC2212860
Free PMC Article

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