Transfusion. 2005 Aug;45(2 Suppl):51S-59S.

Transforming growth factor-beta1, Th1 responses, and autoimmune liver disease.

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Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA. James.Gorham@Dartmouth.edu

Abstract

Transforming growth factor-beta1 (TGF-beta1) is released during the storage of blood components, particularly platelet concentrates, and transfusion recipients are exposed to high levels of TGF-beta1. Because TGF-beta1 is one of the most potent immunosuppressive cytokines known, understanding the immunobiologic functions of TGF-beta1 may be relevant for understanding the immunobiologic effects of transfusion. Our laboratory studies the biologic effects of TGF-beta1 in the immune system. Mice deficient in TGF-beta1 spontaneously develop autoimmunity, confirming the important role of this cytokinean an immune regulator. A few years ago, my laboratory made the observation that genetic background strongly affects the phenotype of TGF-beta1-/- mice. TGF-beta1-/- mice on the BALB/c background rapidly develop an aggressive T-cell-mediated hepatitis, whereas TGF-beta1-/- mice on the 129/CF-1 background do not. In this review, I summarize findings published or in press from our laboratory on disease pathogenesis in TGF-beta1-/- mice and then discuss some of the exciting (as-yet-unpublished) directions our laboratory is currently taking.

PMID:: 16086788; [PubMed - indexed for MEDLINE]

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Transforming growth factor-beta1, Th1 responses, and autoimmune liver disease.
Transforming growth factor-beta1, Th1 responses, and autoimmune liver disease.
Transfusion. 2005 Aug ;45(2 Suppl):51S-59S.

PubMed
MHC-independent genetic regulation of liver damage in a mouse model of autoimmun...
MHC-independent genetic regulation of liver damage in a mouse model of autoimmune hepatocellular injury.
Lab Invest. 2005 Apr ;85(4):550-61.

PubMed
TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through t...
TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1.
J Immunol. 2005 Nov 1 ;175(9):5666-74.

PubMed
Restriction of the CD4+ T-cell receptor repertoire prevents immune pathology in ...
Restriction of the CD4+ T-cell receptor repertoire prevents immune pathology in TGF-beta1 knockout mice.
Lab Invest. 2006 Aug ;86(8):815-28. Epub 2006 Jun 5 .

PubMed
TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T ce...
TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet.
J Immunol. 2005 May 15 ;174(10):5950-8.

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Transforming growth factor-beta1, Th1 responses, and autoimmune liver disease.

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