Int J Biochem Cell Biol. 2005 Nov;37(11):2266-72.

Toxoplasma gondii: microneme protein MIC2.

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Washington University School of Medicine, Department of Microbiology, Campus Box 8230, Saint Louis, MO 63110-1093, USA.

Abstract

The phylum Apicomplexa contains parasites responsible for a variety of diseases including malaria, cryptosporidiosis, and toxoplasmosis. One of the common features of these parasites is that they contain a set of apical organelles whose sequential secretion is required for the invasion of host cells. Microneme proteins are the main adhesins involved in the attachment to the host cell surface by apicomplexans. The microneme protein MIC2, produced by Toxoplasma gondii, is conserved in apicomplexans and serves as a model to understand the first steps of invasion by the phylum. New data about the structure-function relationship of MIC2 reinforce the critical role of this protein in the successful invasion of cells by Toxoplasma and reveal potential therapeutic targets that may be used to control toxoplasmosis.

PMID:: 16084754; [PubMed - indexed for MEDLINE]

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AI B6034/AI/NIAID NIH HHS/United States

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C-terminal processing of the toxoplasma protein MIC2 is essential for invasion into host cells. [J Biol Chem. 2003]
C-terminal processing of the toxoplasma protein MIC2 is essential for invasion into host cells.
Brossier F, Jewett TJ, Lovett JL, Sibley LD. J Biol Chem. 2003 Feb 21; 278(8):6229-34. Epub 2002 Dec 5.
Two separate, conserved acidic amino acid domains within the Toxoplasma gondii MIC2 cytoplasmic tail are required for parasite survival. [J Biol Chem. 2006]
Two separate, conserved acidic amino acid domains within the Toxoplasma gondii MIC2 cytoplasmic tail are required for parasite survival.
Starnes GL, Jewett TJ, Carruthers VB, Sibley LD. J Biol Chem. 2006 Oct 13; 281(41):30745-54. Epub 2006 Aug 21.
Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex. [EMBO J. 2003]
Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex.
Huynh MH, Rabenau KE, Harper JM, Beatty WL, Sibley LD, Carruthers VB. EMBO J. 2003 May 1; 22(9):2082-90.
Review Microneme proteins: structural and functional requirements to promote adhesion and invasion by the apicomplexan parasite Toxoplasma gondii. [Int J Parasitol. 2001]
Review Microneme proteins: structural and functional requirements to promote adhesion and invasion by the apicomplexan parasite Toxoplasma gondii.
Soldati D, Dubremetz JF, Lebrun M. Int J Parasitol. 2001 Oct; 31(12):1293-302.
Review Host cell invasion by the apicomplexans: the significance of microneme protein proteolysis. [Curr Opin Microbiol. 2004]
Review Host cell invasion by the apicomplexans: the significance of microneme protein proteolysis.
Dowse T, Soldati D. Curr Opin Microbiol. 2004 Aug; 7(4):388-96.

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