J Proteome Res. 2005 Jul-Aug;4(4):1143-54.

Place of pattern in proteomic biomarker discovery.

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The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, MA 02141, USA. gillette@broad.mit.edu

Abstract

The role of pattern in biomarker discovery and clinical diagnosis is examined in its historical context. The use of MS-derived pattern is treated as a logical extension of prior applications of non-MS-derived pattern. Criticisms pertaining to specific technology platforms and analytic methodologies are considered separately from the larger issues of pattern utility and deployment in biomarker discovery. We present a hybrid strategy that marries the desirable attributes of high-information content MS pattern with the capability to obtain identity, and explore the key steps in establishing a data analysis pipeline for pattern-based biomarker discovery.

PMID:: 16083265; [PubMed - indexed for MEDLINE]

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