Braz J Med Biol Res. 2005 Aug;38(8):1195-201. Epub 2005 Jul 30.

Volume and energy folding landscape of prion protein revealed by pressure.

Cordeiro Y, Kraineva J, Winter R, Silva JL.

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Instituto de Bioquímica Médica, Centro Nacional de Ressonância Magnética Nuclear de Macromoléculas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

Abstract

The main hypothesis for prion diseases proposes that the cellular protein (PrP C) can be altered into a misfolded, ss-sheet-rich isoform, the PrP Sc (from scrapie). The formation of this abnormal isoform then triggers the transmissible spongiform encephalopathies. Here, we discuss the use of high pressure as a tool to investigate this structural transition and to populate possible intermediates in the folding/unfolding pathway of the prion protein. The latest findings on the application of high pressure to the cellular prion protein and to the scrapie PrP forms will be summarized in this review, which focuses on the energetic and volumetric properties of prion folding and conversion.

PMID:: 16082459; [PubMed - indexed for MEDLINE]

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Volume and energy folding landscape of prion protein revealed by pressure.

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