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[The efficacy of lincomycin in tick-borne encephalitis]
[Article in Russian]
Votiakov VI,
Mishaeva NP,
Protas II,
Ierusalimskiĭ AP,
Shutov AA,
Kovalenko VN,
Kichkil'deev NK,
Samoĭlova TI,
Drakina SA,
Zgirovskaia AA, et al.
Lincomycin was found to inhibit tick-borne encephalitis (TBE) virus. To test antiviral potential of this drug, a clinical trial was initiated entering TBE patients from known focuses of the disease (Novosibirsk, Kemerovo, Perm and Irkutsk Provinces). The drug was given to 23 patients with meningeal and meningoencephalitic TBE. A control group of 22 matched subjects received specific immunoglobulin. Resultant efficacy of lincomycin appeared not inferior to that of anti-TBE immunoglobulin. Lincomycin can be successfully introduced in the treatment of meningeal and meningoencephalitic TBE.
PMID: 1608216 [PubMed - indexed for MEDLINE]
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