Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Behav Neurol. 2005;16(1):41-9.

Wheel-running modestly promotes functional recovery after a unilateral cortical lesion in rats.

Author information

  • 1Department of Neurology, University of Texas, Medical School, Houston, TX 77030, USA.

Abstract

BACKGROUND:

We aimed to determine whether early or delayed wheel-running (W) after a cortical lesion in rats influences functional recovery and protein expression involving synaptic plasticity.

METHODS:

57 rats were arranged in 4 groups: (1) Sham, (2) NMDA, (3) W-24 h or (4) W-72 h (W-24 h and W-72 h means wheel-running for 14 days starting day 1 or day 3 after NMDA lesion). NMDA produced a standardized lesion in the unilateral sensorimotor cortex and detectable behavioral deficits. Synaptogenesis was measured by immunohistochemistry.

RESULTS:

Wheel-running starting after 24 h had no detectable effect, but it significantly speeded functional recovery when delayed to after 72 h. These results were in accordance with a marker linked to synaptogenesis.

CONCLUSION:

Wheel-running starting 3 days, but not 1 day, after an NMDA lesion is associated with improved functional recovery.

PMID:
16082079
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for IOS Press
    Loading ...
    Write to the Help Desk