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BMJ. 2005 Aug 6;331(7512):324-9.

Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial.

Author information

  • 1Health Services Research Unit, School of Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD. a.avenell@abdn.ac.uk

Abstract

OBJECTIVE:

To examine whether supplementation with multivitamins and multiminerals influences self reported days of infection, use of health services, and quality of life in people aged 65 or over.

DESIGN:

Randomised, placebo controlled trial, with blinding of participants, outcome assessors, and investigators.

SETTING:

Communities associated with six general practices in Grampian, Scotland.

PARTICIPANTS:

910 men and women aged 65 or over who did not take vitamins or minerals.

INTERVENTIONS:

Daily multivitamin and multimineral supplementation or placebo for one year.

MAIN OUTCOME MEASURES:

Primary outcomes were contacts with primary care for infections, self reported days of infection, and quality of life. Secondary outcomes included antibiotic prescriptions, hospital admissions, adverse events, and compliance.

RESULTS:

Supplementation did not significantly affect contacts with primary care and days of infection per person (incidence rate ratio 0.96, 95% confidence interval 0.78 to 1.19 and 1.07, 0.90 to 1.27). Quality of life was not affected by supplementation. No statistically significant findings were found for secondary outcomes or subgroups.

CONCLUSION:

Routine multivitamin and multimineral supplementation of older people living at home does not affect self reported infection related morbidity.

TRIAL REGISTRATION:

ISRCTN: 66376460.

Comment in

PMID:
16081445
[PubMed - indexed for MEDLINE]
PMCID:
PMC1183131
Free PMC Article

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