Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mol Neurobiol. 2005 Aug;32(1):51-7.

Cortical spreading depression modifies components of the inflammatory cascade.

Author information

  • 1Neuroscience Research Program, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario.

Abstract

As more information becomes available regarding the role of inflammation following stroke, it is apparent that some inflammatory mediators are detrimental and others are beneficial to the progression of ischemic injury. Cortical spreading depression (CSD) is known to impart some degree of ischemic tolerance to the brain and to influence the expression of many genes. Many of the genes whose expression is altered by CSD are associated with inflammation, and it appears likely that modulation of the inflammatory response to ischemia by CSD contributes to ischemic tolerance. Understanding which inflammatory processes are influenced by CSD may lead to the identification of novel targets in the effort to develop an acute treatment for stroke.

PMID:
16077183
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk