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Bioinformatics. 2005 Sep 15;21(18):3669-71. Epub 2005 Aug 2.

GenColors: accelerated comparative analysis and annotation of prokaryotic genomes at various stages of completeness.

Author information

  • 1Biocomputing Group, Institute of Molecular Biotechnology, 07745 Jena, Germany.

Abstract

SUMMARY:

GenColors is a new web-based software/database system aimed at an improved and accelerated annotation of prokaryotic genomes, considering information on related genomes and making extensive use of genome comparison. It offers a seamless integration of data from ongoing sequencing projects and annotated genomic sequences obtained from GenBank. The genome comparison tools determine, for example, best-bidirectional hits, gene conservation, syntenies and gene core sets. Swiss-Prot/TrEMBL hits allow annotations in an effective manner. To further support the annotation base-specific quality data can also be displayed if available. With GenColors dedicated genome browsers containing a group of related genomes can be easily set up and maintained. It has been efficiently used for Borrelia garinii and is currently applied to various ongoing genome projects.

AVAILABILITY:

Detailed information on GenColors is available at http://gencolors.imb-jena.de. Online usage of GenColors-based genome browsers is the preferred application mode. The system is also available upon request for local installation.

PMID:
16076887
[PubMed - indexed for MEDLINE]
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