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1: Ear Nose Throat J. 2005 Jun;84(6):366-8.Links

Peritonsillar abscess: a comparison of outpatient i.m. clindamycin and inpatient i.v. ampicillin/sulbactam following needle aspiration.

Ozbek C, Aygenc E, Unsal E, Ozdem C.

Department of Otolaryngology-Head and Neck Surgery, Ankara Numune Research and Education Hospital, Ankara, Turkey. mcemozbek@yahoo.com

In an attempt to assess the effect of antibiotic choice on the treatment of peritonsillar abscess, we compared the clinical efficacy of empiric intramuscular clindamycin and intravenous ampicillin/sulbactam (following needle aspiration of the abscess) in a prospective, randomized study of 58 patients. Patients in the clindamycin group were treated on an outpatient basis, whereas those in the ampicillin/sulbactam group were hospitalized for the duration of their treatment (minimum: 7 days). Comparison of clinical outcomes with respect to the posttherapeutic duration of fever and throat pain and the time to resumption of eating revealed no statistically significant difference between the two groups. These results suggest that intramuscular clindamycin is an excellent choice and can be safely prescribed on an outpatient basis following needle aspiration, thereby reducing both antibiotic and hospital costs.

PMID: 16075861 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Penicillin G Potassium or Sodium Injection (Pfizerpen® )

    Your doctor has ordered penicillin, an antibiotic, to help treat your infection. The drug will be either injected into a large muscle (such as your buttock or hip) or added to an intravenous fluid that will drip through ...

  • Clindamycin (Cleocin® )

    Clindamycin is used to treat certain types of bacterial infections, including infections of the lungs, skin, blood, female reproductive organs, and internal organs. Clindamycin is in a class of medications called lincomy...

  • Ampicillin Sodium Injection (Principen® )

    Your doctor has ordered ampicillin, an antibiotic, to help treat your infection. The drug will be either injected into a large muscle (such as your buttock or hip) or added to an intravenous fluid that will drip through ...

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