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Opt Lett. 2005 Jul 1;30(13):1689-91.

Portable in situ fluorescence cytometry of microscale cell-based assays.

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  • 1School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14850, USA.


A portable fluorescence cytometric system has been developed for characterizing chemical concentration and cellular status in microscale cell culture analog (microCCA) devices. Based on discrete optical components, the system provides a modular platform for real-time image measurements applicable to a variety of cell-based microassays. As a feasibility study, we investigated the real-time dynamics of daunorubicin uptake with cultured mouse L-cells in a microCCA compartment. Time course results measured by the portable fluorescence cytometric system confirmed that in the microCCA devices daunorubicin accumulation is proportional to the liquid turnover rate.

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