Rapidly growing giant suprasellar tumor in a high-risk child: treatment strategy and role of neuroendoscopic surgery in slit-like ventricles

Childs Nerv Syst. 2006 Apr;22(4):403-8. doi: 10.1007/s00381-005-1156-y. Epub 2005 Jun 17.

Abstract

Rationale: Suprasellar tumors are common in the pediatric population and exhibit a wide range of pathological appearance and behavior. Although rare, pure suprasellar germinomas carry worse prognosis than other locations.

Methods: We present a case of a 10-year-old girl treated with therapeutic anticoagulation for previous cardiac valvular replacement, who presented with rapidly growing giant (>4 cm) suprasellar germinoma. Neoadjuvant chemotheraphy was effective and the dilated ventricles became slit-like. The fine free-hand maneuver using a fine rigid-rod neuroendoscope. "Oi-Samii Handy Pro" made it possible to obtain the tissue diagnosis.

Results: Complete remission was achieved using neoadjuvant chemotherapy, minimally invasive neuroendoscopic surgery, then followed by specific chemoradiotherapy.

Conclusion: The role of neuroendoscopic procedure, performed in a difficult situation with normalized size of the ventricles, was emphasized.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / radiotherapy
  • Brain Neoplasms / surgery*
  • Cerebral Ventricles / pathology
  • Cerebral Ventricles / surgery*
  • Chemotherapy, Adjuvant
  • Child
  • Combined Modality Therapy
  • Female
  • Germinoma / drug therapy
  • Germinoma / radiotherapy
  • Germinoma / surgery*
  • Humans
  • Magnetic Resonance Imaging
  • Neuroendoscopy / methods*
  • Neurosurgical Procedures / methods
  • Sella Turcica
  • Treatment Outcome