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1: J Clin Invest. 2005 Aug;115(8):2018-24.Click here to read Click here to read Links

Long QT syndrome: from channels to cardiac arrhythmias.

Moss AJ, Kass RS.

Heart Research Follow-up Program, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA. heartajm@heart.rochester.edu

Long QT syndrome, a rare genetic disorder associated with life-threatening arrhythmias, has provided a wealth of information about fundamental mechanisms underlying human cardiac electrophysiology that has come about because of truly collaborative interactions between clinical and basic scientists. Our understanding of the mechanisms that control the critical plateau and repolarization phases of the human ventricular action potential has been raised to new levels through these studies, which have clarified the manner in which both potassium and sodium channels regulate this critical period of electrical activity.

PMID: 16075042 [PubMed - indexed for MEDLINE]

PMCID: PMC1180552

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