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Nat Rev Mol Cell Biol. 2005 Aug;6(8):599-609.

Ubiquitin and ubiquitin-like proteins as multifunctional signals.

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  • 1School of Biomedical Sciences,University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK.


Protein ubiquitylation is a recognized signal for protein degradation. However, it is increasingly realized that ubiquitin conjugation to proteins can be used for many other purposes. Furthermore, there are many ubiquitin-like proteins that control the activities of proteins. The central structural element of these post-translational modifications is the ubiquitin superfold. A common ancestor based on this superfold has evolved to give various proteins that are involved in diverse activities in the cell.

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