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J Exp Med. 2005 Aug 1;202(3):337-40.

Macrophage fusion: the making of osteoclasts and giant cells.

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  • 1Yale University School of Medicine, New Haven, CT 06510, USA. agnes.vignery@yale.edu

Abstract

The fusion of cells is a fundamental biological event that is essential for a variety of developmental and homeostatic processes. Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the mechanisms that govern these processes are poorly understood. A new study now reveals an unexpected role for the receptor, dendritic cell-specific transmembrane protein (DC-STAMP), in this process. The potential mechanism by which DC-STAMP governs fusion and the implications of this finding will be discussed.

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