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Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9.

SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.

Author information

  • 1Organix Inc., 240 Salem Street, Woburn, MA 01801, USA. sard@organixinc.com

Abstract

An SAR study of psilocybin and psilocin derivatives reveals that 1-methylpsilocin is a selective agonist at the h5-HT(2C) receptor. The corresponding phosphate derivative, 1-methylpsilocybin, shows efficacy in an animal model for obsessive-compulsive disorder, as does 4-fluoro-N,N-dimethyltryptamine. These results suggest a new area for development of novel 5-HT(2C) agonists with applications for drug discovery.

PMID:
16061378
[PubMed - indexed for MEDLINE]
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