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    Arch Toxicol. 1992;66(2):143-4.

    Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice.

    Clement JG.

    Source

    Biomedical Defence Section, Defence Research Establishment Suffield, Ralston, Alta., Canada.

    Abstract

    The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combinations of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffective. HI-6 was the only oxime which reactivated GF inhibited acetylcholinesterase. This might explain the reason why the HI-6 treated mice appeared to recover more quickly from the incapacitating effects following GF poisoning.

    PMID:
    1605730
    [PubMed - indexed for MEDLINE]

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