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Neuroreport. 2005 Aug 22;16(12):1267-70.

Amygdala reactivity to emotional faces predicts improvement in major depression.

Author information

  • 1Department of Psychology, Stony Brook University, Stony Brook, NY 11794-2500, USA.

Abstract

Behavioral studies suggest that emotional reactivity in depressed persons predicts subsequent symptom reduction. Using functional magnetic resonance imaging in a prospective study, we show that greater amygdala activation to emotional facial expressions among depressed patients predicts symptom reduction 8 months later, controlling for initial depression severity and medication status. Functional magnetic resonance imaging may thus be used as a method to identify neural markers in depressed patients at risk for poor outcome.

PMID:
16056122
[PubMed - indexed for MEDLINE]
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