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Immunol Lett. 2005 Aug 15;100(1):21-8.

CD28 superagonists: mode of action and therapeutic potential.

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  • 1Institute for Virology and Immunology, University of Würzburg, Versbacher Strasse 7, 97078 Würzburg, Germany.


Some CD28-specific monoclonal antibodies (mAbs) have the surprising property to activate T-cells without the need for TCR ligation. This review summarizes the differences between these "superagonistic" and conventional CD28-specific mAbs with regard to binding specificity and signalling properties. Furthermore, the dramatic effects of in vivo application of CD28 superagonists with regard to the induction of regulatory T-cells and polyclonal T-cell expansion in lymphopenic settings are discussed under the aspect of potential therapeutic applications.

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