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Microbes Infect. 2005 Oct;7(13):1364-9. Epub 2005 Jun 24.

Decoding Tat: the biology of HIV Tat posttranslational modifications.

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  • 1Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

Abstract

The Tat protein is a viral transactivator that activates HIV transcription through complex interactions with RNA and host cell factors. Tat undergoes multiple posttranslational modifications that regulate the dynamics and complexity of these interactions. The biology of these modifications and their role in Tat function are reviewed.

PMID:
16046164
[PubMed - indexed for MEDLINE]
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