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Semin Cell Dev Biol. 2005 Dec;16(6):683-93. Epub 2005 Jul 25.

Specification of neural crest cell formation and migration in mouse embryos.

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  • 1Stowers Institute for Medical Research, Kansas City, MO 64110, USA.


Of all the model organisms used to study human development, rodents such as mice most accurately reflect human craniofacial development. Collective advances in mouse embryology and mouse genetics continue to shape our understanding of neural crest cell development and by extrapolation the etiology of human congenital head and facial birth defects. The aim of this review is to highlight the considerable progress being made in our understanding of cranial neural crest cell patterning in mouse embryos.

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