Biochem Soc Trans. 2005 Aug;33(Pt 4):796-801.

Biodiversity of cytochrome P450 redox systems.

McLean KJ, Sabri M, Marshall KR, Lawson RJ, Lewis DG, Clift D, Balding PR, Dunford AJ, Warman AJ, McVey JP, Quinn AM, Sutcliffe MJ, Scrutton NS, Munro AW.

Source

Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, UK. kjm20@le.ac.uk

Abstract

P450s (cytochrome P450 mono-oxygenases) are a superfamily of haem-containing mono-oxygenase enzymes that participate in a wide range of biochemical pathways in different organisms from all of the domains of life. To facilitate their activity, P450s require sequential delivery of two electrons passed from one or more redox partner enzymes. Although the P450 enzymes themselves show remarkable similarity in overall structure, it is increasingly apparent that there is enormous diversity in the redox partner systems that drive the P450 enzymes. This paper examines some of the recent advances in our understanding of the biodiversity of the P450 redox apparatus, with a particular emphasis on the redox systems in the pathogen Mycobacterium tuberculosis.

PMID:: 16042601; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Review P450BM-3; a tale of two domains--or is it three? [Steroids. 1997]
Review P450BM-3; a tale of two domains--or is it three?
Peterson JA, Sevrioukova I, Truan G, Graham-Lorence SE. Steroids. 1997 Jan; 62(1):117-23.
Review Cytochrome P450--redox partner fusion enzymes. [Biochim Biophys Acta. 2007]
Review Cytochrome P450--redox partner fusion enzymes.
Munro AW, Girvan HM, McLean KJ. Biochim Biophys Acta. 2007 Mar; 1770(3):345-59. Epub 2006 Aug 30.
Review The preponderance of P450s in the Mycobacterium tuberculosis genome. [Trends Microbiol. 2006]
Review The preponderance of P450s in the Mycobacterium tuberculosis genome.
McLean KJ, Clift D, Lewis DG, Sabri M, Balding PR, Sutcliffe MJ, Leys D, Munro AW. Trends Microbiol. 2006 May; 14(5):220-8. Epub 2006 Apr 3.
Review CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen. [Biochem Soc Trans. 2006]
Review CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen.
McLean KJ, Dunford AJ, Sabri M, Neeli R, Girvan HM, Balding PR, Leys D, Seward HE, Marshall KR, Munro AW. Biochem Soc Trans. 2006 Dec; 34(Pt 6):1178-82.
Structure of a cytochrome P450-redox partner electron-transfer complex. [Proc Natl Acad Sci U S A. 1999]
Structure of a cytochrome P450-redox partner electron-transfer complex.
Sevrioukova IF, Li H, Zhang H, Peterson JA, Poulos TL. Proc Natl Acad Sci U S A. 1999 Mar 2; 96(5):1863-8.

See reviews... See all...

Cited by 7 PubMed Central articles

Prediction and analysis of the modular structure of cytochrome P450 monooxygenases. [BMC Struct Biol. 2010]
Prediction and analysis of the modular structure of cytochrome P450 monooxygenases.
Sirim D, Widmann M, Wagner F, Pleiss J. BMC Struct Biol. 2010 Oct 15; 10:34. Epub 2010 Oct 15.
Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis. [J Biol Chem. 2010]
Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis.
Xu LH, Fushinobu S, Takamatsu S, Wakagi T, Ikeda H, Shoun H. J Biol Chem. 2010 May 28; 285(22):16844-53. Epub 2010 Apr 7.
Mammalian cytochrome CYP2E1 triggered differential gene regulation in response to trichloroethylene (TCE) in a transgenic poplar. [Funct Integr Genomics. 2010]
Mammalian cytochrome CYP2E1 triggered differential gene regulation in response to trichloroethylene (TCE) in a transgenic poplar.
Kang JW, Wilkerson HW, Farin FM, Bammler TK, Beyer RP, Strand SE, Doty SL. Funct Integr Genomics. 2010 Aug; 10(3):417-24. Epub 2010 Mar 9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Biodiversity of cytochrome P450 redox systems.
Biodiversity of cytochrome P450 redox systems.
Biochem Soc Trans. 2005 Aug ;33(Pt 4):796-801.

PubMed
Regulation of peroxisome proliferator-activated receptor alpha by protein kinase...
Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C.
Biochemistry. 2005 Aug 2 ;44(30):10313-21.

PubMed
Human carbonic anhydrase III: structural and kinetic study of catalysis and prot...
Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer.
Biochemistry. 2005 Aug 2 ;44(30):10046-53.

PubMed
The association between cognitive impairment and physical disability in multiple...
The association between cognitive impairment and physical disability in multiple sclerosis.
Mult Scler. 2005 Aug ;11(4):469-76.

PubMed
Cholesterol pericarditis--relapsing pericardial effusion in a patient with rheum...
Cholesterol pericarditis--relapsing pericardial effusion in a patient with rheumatoid arthritis.
Rev Port Cardiol. 2005 May ;24(5):737-45.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Biodiversity of cytochrome P450 redox systems.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 7 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information