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J Dent Res. 2005 Aug;84(8):678-90.

Epithelial-mesenchymal transformation during craniofacial development.

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  • 1Graduate Endodontics Department, Texas A&M University System, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75266, USA.


Epithelial to mesenchymal phenotype transition is a common phenomenon during embryonic development, wound healing, and tumor metastasis. This transition involves cellular changes in cytoskeleton architecture and protein expression. Specifically, this highly regulated biological event plays several important roles during craniofacial development. This review focuses on the regulation of epithelial-mesenchymal transformation (EMT) during neural crest cell migration, and fusion of the secondary palate and the upper lip.

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