3-(2-Aminoethyl)pyridine analogs as alpha4beta2 ni...[Bioorg Med Chem Lett. 2005]

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1: Bioorg Med Chem Lett. 2005 Oct 1;15(19):4308-12. Links

3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands.

Dukat M, Ramunno A, Banzi R, Damaj MI, Martin B, Glennon RA.

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.

An examination of several 3-(2-aminoethyl)pyridine analogs suggests that they likely orient at alpha4beta2 nicotinic cholinergic receptors in a different fashion than their correspondingly substituted nicotine analogs.

PMID: 16039854 [PubMed - indexed for MEDLINE]

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Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity. [AAPS J. 2005]
A comparison of the binding of three series of nicotinic ligands. [Bioorg Med Chem Lett. 2002]
2. Medicinal chemistry of alpha4beta2 nicotinic cholinergic receptor ligands. [Prog Med Chem. 2004]
Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor. [Bioorg Med Chem Lett. 2000]
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3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands.

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