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Biochim Biophys Acta. 2005 Dec 30;1746(3):274-83. Epub 2005 Jun 27.

Ras signaling from plasma membrane and endomembrane microdomains.

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  • 1Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia.


Ras proteins are compartmentalized by dynamic interactions with both plasma membrane microdomains and intracellular membranes. The mechanisms underlying Ras compartmentalization involve a series of protein/lipid, lipid/lipid and cytoskeleton interactions, resulting in the generation of discrete microdomains from which Ras operates. Segregation of Ras proteins to these different platforms regulates the formation of Ras signaling complexes and the generation of discrete signal outputs. This temporal and spatial modulation of Ras signal transduction provides a mechanism for the generation of different biological outcomes from different Ras isoforms, as well as flexibility in the signal output from a single activated isoform.

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