J Mol Cell Cardiol. 2005 Aug;39(2):377-87.

Myocardial regeneration by endogenous adult progenitor cells.

Müller P, Beltrami AP, Cesselli D, Pfeiffer P, Kazakov A, Böhm M.

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Klinik für Innere Medizin III, Kardiologie, Angiologie and internistische Intensivmedizin, Universität des Saarlandes, Kirrberger Strasse, D-66421 Homburg/Saar, Germany.

Abstract

New strategies are urgently needed for the treatment of terminal heart-failure. Recently, new therapeutic strategies were developed to induce cardiac regeneration and thereby enhancing myocardial performance by using the patients own cell pool. In the quest for adequate donor cells skeletal myoblasts, bone marrow (BM) derived cells, endothelial progenitor cells (EPCs) and resident cardiac stem cells but also cytokine application were examined. This review critically discusses the recent findings in the field of endogenous adult progenitor cells and proposes new areas for future research.

PMID:: 16038708; [PubMed - indexed for MEDLINE]

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