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Acta Cir Bras. 2005 May-Jun;20(3):213-8.

Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholism.

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  • 1Departamento de Cirurgia e Anestesiologia Veterinária, Faculdade de Medicina Veterinária e Zootecnia de Botucatu, School of Veterinary Medicine and Animal Science, UNESP-São Paulo State University, Botucatu. nereide@fmvz.unesp.br

Abstract

PURPOSE:

To assess the influence of experimental chronic alcoholism in the morphology and biomechanics of the aorta, in a rat model.

METHODS:

Forty-four Wistar rats were randomly divided into two groups of 22 animals each: in the alcoholism group, the rats received water mixed to increasing concentrations of ethyl alcohol; and control group: the rats received pure water for 180 days. The animals were then killed by an overdose of pentobarbital and the abdominal aortas were excised for histological (hematoxylin-eosin, Masson, Calleja, and Picrosirius red stain), histomorphometrical, and biomechanical analysis.

RESULTS:

Histology and histomorphometry did not show differences in aorta morphology of both groups. Biomechanical analysis showed a significantly greater yield point elongation in the alcoholic rat group (p < 0.05).

CONCLUSION:

Chronic alcoholism did not cause morphological alterations in the aortic wall but increased elongation, without modifying any other mechanical properties.

PMID:
16033179
[PubMed - indexed for MEDLINE]
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