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1: Vaccine. 2005 Sep 23;23(40):4860-6.Click here to read Links

The potential of phage display virions expressing malignant tumor specific antigen MAGE-A1 epitope in murine model.

Fang J, Wang G, Yang Q, Song J, Wang Y, Wang L.

School of Life Sciences, Northeast Normal University, 5268 Renmin Street, Nanguan District, Changchun 130024, PR China.

The tumor specific antigen epitope melanoma antigen A1(161--169) (MAGE-A1(161--169)) was displayed on the major protein (p VIII) of the filamentous bacteriophage (fd). The immune responses of the phage display particles expressing MAGE-A1(161--169) in mice were studied. Using phage display particles as vaccine was effective in affording protection from tumor growth, inducing growth control of established tumors and prolonging survival of tumor-bearing mice. The hybrid phage particles elicited MAGE-A1(161--169) specific CTL responses, NK activity and DTH. Our results showed that the phage display particles might be a new vaccine candidate for tumor-associated antigen epitope in cancer immunotherapy.

PMID: 16029917 [PubMed - indexed for MEDLINE]